KMID : 0043319940170040281
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Archives of Pharmacal Research 1994 Volume.17 No. 4 p.281 ~ p.283
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Synthesis of New Hydantoin-3-Ethanethioi Derivatives
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Oh Chang-Hyun
Lee Ki-Soo Roh Eun-Joo Kwon Soon-Kyoung Cho Jung-Hyuck
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Abstract
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5-sec-butylthiomethyl-5-alkyl (methyl or phenyl) hydantoins (3-x) were prepared by the reaction of sec-buylthiomethyl alkyl (methyl or phenyl) ketone (1-2), potassium cyanide and ammonium carbonate. 3-(2-Bromoethyl) hydantoins (5-6) were the reaction products of 5-sec-buythiomethyl-5-alkyl (methyl or phenyl) hydantoin and 1, 2-dibromothane in the presence of potassium hydroxide. Alkylation of 5 and 6 with an excess of alkyl (methyl or ethyl iodide in THF with sodium hydride as base gave three 1-alkyl (methyl or ethyl)-3-(2-bromoethyl) hydantoins (7-9). Treatment of the 2-bromothyl group with potassium thioacelate and triethylamine gave three 1-alkyl (methyl or ethyl)-3-92-acetylthioethyl) hydantoins (10-12). Hydrolysis of the 2-acetylthiuoethyl group with sodium hydroxide in methanol afforded the three 1-alkyl (methyl or ethyl)-3-(2-mercaptorthyl) hydantoins.
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KEYWORD
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Synthesis, Hydantoin-3-ethanethiol, Anti-inflammatory activity, Analgesic activity
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